Tagata BCR-ABL Fusion Gene Mutation

Fa'amatalaga Puupuu:

O lenei pusa e fetaui lelei mo le suʻesuʻeina lelei o p190, p210 ma p230 isoforms o le BCR-ABL fusion gene i faʻataʻitaʻiga o gaʻo ponaivi o tagata.


Fa'amatalaga Oloa

Faailoga o oloa

Igoa o oloa

HWTS-GE010A-Tagata BCR-ABL Fusion Gene Mutation Detection Kit (Fluorescence PCR )

Epidemiology

Chronic myelogenousleukemia (CML) ose fa'ama'i fa'ama'i fa'ama'i fa'ama'i o sela o le hematopoietic stem cell.E sili atu i le 95% o tagata gasegase CML o loʻo tauaveina le Philadelphia chromosome (Ph) i totonu o latou toto.O faʻamaʻi faʻamaʻi o le CML e faʻapea: O le BCR-ABL fusion gene e faʻavaeina e ala i se faʻaliliuga i le va o le abl proto-oncogene (Abelson murine leukemia viral oncogene homolog 1) i luga o le lima umi o le chromosome 9 (9q34) ma le vaega o fuifui breakpoint ( BCR) gene i le lima umi o le chromosome 22 (22q11);o le polotini fusu'aga ua fa'ailogaina e lenei kene ei ai le tyrosine kinase (TK), ma fa'agaoioia ana ala fa'ailoga i lalo (e pei o le RAS, PI3K, ma le JAK/STAT) e fa'aolaina ai le vaeluaga o le sela ma fa'alavelaveina le apoptosis sela, ma fa'atupu ai le fa'atupuina leaga o sela, ma mafua ai ona tupu. le tupuga o le CML.O le BCR-ABL o se tasi o faʻailoga taua o le CML.O le suiga malosi o lona tulaga fa'amaumauga o se fa'ailo mautu mo le fa'atonuga fa'apitoa o le lukimia ma e mafai ona fa'aoga e va'ai ai le toe tupu mai o le lukimia pe a uma togafitiga.

Auala

FAM BCR-ABL fusion gene
VIC/HEX Pulea i totonu

Vaega Fa'atekinisi

Teuina Suavai: ≤-18℃ I le pogisa
Fa'asa-ola Suavai: 9 masina
Ituaiga Fa'ata'ita'iga Fa'ata'ita'iga o ga'o ponaivi
LoD 1000 kopi/ml

Fa'apitoa

 

E leai se fesoʻotaʻiga faʻatasi ma isi genes fusifusia TEL-AML1, E2A-PBX1, MLL-AF4, AML1-ETO, ma PML-RARa
Meafaigaluega Faatatau Fa'aogaina Biosystems 7500 Fa'atonu PCR Taimi Moni

Fa'aogaina Biosystems 7500 Fa'atonuga PCR Taimi Moni Anapogi

QuantStudio® 5 Faiga PCR Taimi Moni

SLAN-96P Faiga PCR Taimi Moni

LightCycler®480 Taimi moni PCR faiga

LineGene 9600 Plus Faiga Fa'amatalaga PCR Taimi Moni

MA-6000 Taimi Moni Fa'ata'amiloga Fa'avevela

BioRad CFX96 Taimi Moni PCR System

BioRad CFX Opus 96 Taimi moni PCR System


  • Muamua:
  • Sosoo ai:

  • Tusi lau savali iinei ma lafo mai ia i matou