O se auupega fou mo Tuberculisis Diginosis ma Fualaʻau Resicance Resociation: O se augatupulaga fou o loʻo faʻatautaia ai le liberculis o le suʻega
RESIDAS RAMES: CCA: O se ata faʻapitoa e faʻavae i luga o le Tngs ma masini aʻoaʻoga, lea e talafeagai mo tagata e itiiti ifo ma tibrecias
O le ulutala ulutala: tupeta-traping-tragetted i le isi-augatupulaga sequening ma masini toleniga: O le ungatra-togafiti togafiti mo ubular o tubulars o tubular.
Vaitaimi: "Clinica Chimbica Gaxi"
Afai: 6.5
Aso o le Lomiga: Ianuari 2024
Tuʻufaʻatasia ma le Iunivesite o Saina Academy of Sciences ma Beijing Chest Hosper of Invess University, Macro-Suʻega o le The New Steences, o le mea e aʻoaʻoina ai mauaina lagona lelei mo le uberculis i nai siama ma tiberteria ma tubremily menitis, maua ai se fou hypersivity diagnosis metotia mo O le fomaʻi faʻapitoa o le lua ituaiga o le uberculisis, ma fesoasoani i le saʻo pipisi, vailaʻau o vailaʻau o loʻo iloa ai ma togafitiga. I le taimi lava e tasi, ua maua ai o le tagata gasegase Plasma Cfdna e mafai ona faʻaaogaina o se talafeagai faʻataʻitaʻiga ituaiga mo le faʻapopoleina o le tbm.
I lenei suʻesuʻega, 227 plasma ma faʻataʻitaʻiga ma cerebropinal vai faʻapitoa sa faʻaaoga e faʻavae ai le lua o aʻoga faʻapitoa, ma o le fale suʻesuʻe na faʻaaogaina e faʻamaonia ai ata tifaga. O faʻataʻitaʻiga uma sa muamua faʻaaogaina e se faʻapitoa fuafuaina o le puʻeina o le probe pol mo le mycobactactium tuberculos. Ma, faʻavae i luga o le TB-TNGS Conquencess Data, o le faʻataʻitaʻiga faʻataʻitaʻi o loʻo masani ai e faʻatino ai le 5-Fronk Cross-faʻamaoniaina o le Lacesma Races e mauaina. O le mea na mauaina o le mea na maua e aumaia i totonu o le lua suʻega seti o le falemaʻi o loʻo fuafuaina mo le mauaina, ma le suʻega o le tagata aʻoaʻo e iloiloina e le tagata aʻoaʻo. Ma le mea mulimuli, o le faʻailoga faʻataʻitaʻiga o Tubercusis na mauaina.
Ata 1 Schematic ata o suʻesuʻega mamanu
Iuga: E tusa ai ma le faʻapitoa o le CSF Dna faʻataʻitaʻiga (AUC = 0.974) ma plasma cfdna faʻataʻitaʻiga o le 95.65% o le 95.65%, ma O le malamalamaʻaga ma le mea faʻapitoa o Prisma Stric na 82.61% ma le 86.36%. I le auiliiliga o le ata tifaga o le ata o Plasma Cfdna ma Cerebrophinal Slud Dona mai TBM Preyments o le 95.4.45% o le 95.4.45% (42/44). I tamaiti ma le Pumomory Tubercusis, o le Diagostic fuafuaga o lenei suʻesuʻega e sili atu le maaleale i plasma faʻataʻitaʻiga o faʻataʻitaʻiga o le siama i le tagata gasegase.
Ata 2 Iloiloga Faʻatino o Tuberculosis Digignosis faʻataʻitaʻiga mo le faitau aofai o tagata
Ata 3 dignostic iuga o le faapopoleina o faʻataʻitaʻiga
Faaiuga: O se faʻataʻitaʻiga o le faʻataʻitaʻiga o le Diagnostic Product mo Tuberculosis na faʻatuina i lenei suʻesuʻega, e mafai ona maua ai se mea e te maua ai le poto masani o le olicbalry (le lelei aganuu). O le mauaina o le faʻailoga o le faʻailoga o le tiberculosis e faʻavae i luga o plasma Cfdna e ono avea o se talafeagai faʻataʻitaʻiga ituaiga mo le faʻailoaina o le oona (plasmal o le vailaʻau o loʻo faigofie ai o le anrebroplis).
Uluai fesoʻotaʻiga: HTTPS://www.sprentdiredred.com/scathetity/article/pii/PII/S0009898123004990? Via% 3Dihub
Faatomuga puʻupuʻu o Macro & Micro-Schoop Tubercusis Faʻasologa o le iloa oloa
Ile vaʻai atu i le faigata o le faʻataʻitaʻiga o le faʻataʻitaʻiga o tubercusis tagata gasegase ma le tele o manaʻoga, macro & bir-suc-suʻega o loʻo maua ai se faʻasologa o mea 'eseʻese. O le oloa e aofia ai faʻailoga vave o le tuberculisis tagata gasegase, vailaʻau tetee o tiberculis, o le a le le lelei o le o le siama o le siama, ma isi
Faʻasalaina o le Real Daits mo Taberculosis ma MyCabacterlia:
Aitema leai | Igoa o oloa | Oloa Susuga Mataupu | Faʻataʻitaʻiga ituaiga | Talosaga talafeagai |
Hwts-3012 | Faapitoa Tatalaina Suiga | Faaaogaina i le auala feololo o faʻataʻitaʻiga o faʻataʻitaʻiga, ua maua ai se numera faʻamaumauga muamua-vasega, suka masini 20230047. | fulufulu | |
Hwts-ngs-p00021 | Aotelega o le tomai o le siakiina o le pusa mo le fiafia o le tiberculisive (probe sport metotia) | Le-le-osofaʻiga (suavai biopsy) o le le mautonu o le mafaufau mo siama e le masani ai o le siamuni o le pulmary ma le mafaufau; O faʻataʻitaʻiga o tagata masalomia o le aʻafia i le tuberculisis poʻo le le-tibercucis o loʻo suʻesuʻeina pe o le faʻafanua muamua-laina na saunia. | O le toto toto, Alveolalar LaVage Finad, Hydrothorax ma Asclaites, Taulaitu Camctage faʻataʻitaʻiga, Cerebropal vai. | Lua Tupulaga |
Hwts-ngs-t001 | Mycobacterailine typpine ma fualaau faasaina o le resictiction disgiget ki (tele le tele o le auala | Mycobacterum typping suega, aofia ai ma le MTBC ma 187 NTM;Fualaʻau Resictiction Disction of Mycobacterphium Buberculosis Covers 13 Vailaau ma 16 Core Sgat of the Consictions Force. | Sputum, alveolalalar solvage vai, hydrothoraxx ma Asclaites, taulai carcture faʻataʻitaʻiga faʻataʻitaʻiga, cerebropal vai. | Lua / Tuapuaga o le Tupulaga Itumalo |
Manatu Tāua: HWTS-NGS-T001 Mycobactageium typpines ma fualaau faasaina o le Disction Disctiction (tele-Agmp Amplication Metotia)
Oloa Folasaga
O le oloa e faʻavae i luga o le autu muamua-ma le lua-laina vailaʻau faʻamatalaina i le teve dra deces taiala, mahroroscosidescosides e masani ona faʻaaogaina i nofoaga ext. O ai o le Mycobactertam Tuberculis Roadx Musetion Rutalog, atoa foi ma isi lipotia fualaau faasaina o General Retrications Genes Geness and Stations o tusitusiga ma fuainumera. fale ma fafo.
O le faʻailoaina o le faʻailoaina o loʻo faʻavae i luga o le NTM Systemis o loʻo aoina e le NTM taiala na lomia e le au tusitala Saina o Tuberculois Dirests ma le maliega. O le mamanuina o le taina o Play Prices e mafai ona faʻalauteleina, faʻasologa ma le le lava sili atu nai lo le 190 NTM ituaiga.
E ala i le faʻatatauina o le tele o le tekinolosi o le tekonolosi, o le auvaʻa o meaola ma fualaau faasaina o le mecobactium o le prock pcr, ma le armlicon tuufaatasiga o le taulaiga o le pcer e iloa ai. O oloa faagaeeina e mafai ona fausia i le lona lua-augatupulaga ma le lona tolu-augatupulaga o loʻo faʻatulagaina faletusi, ma tolu-augatupulaga o loʻo mafai ona faʻatinoina le faʻasologa o le promentation. I le faʻatusatusaina ma le iloa o le faʻaaogaina o loʻo iai i totonu o le faʻamaumauga o faʻamaumauga (aofia ai ma le o loʻo fuafuaina i le faʻafanua poʻo le faigofie o fualaau faasaina. Tuufaatasi ma le tagata lava ia-tatalaina sputum faʻataʻitaʻiga togafitiga o Macro & Micro-Suʻega, o le faʻafitauli o le maualalo o le faʻafanua o faʻataʻitaʻiga faʻaaogaina saʻo i le feisaiga slutum faʻataʻitaʻiga.
Oloa maua fua
34fualaau faasaina tetee-uiga o le18anti-tibercusis fualaau faasaina ma6Na iloa fualaau faasaina a NTM, ufiufi297Nofoaga o le tetee atu i ai; Sefulu ituaiga o Mycobacter i Tuberculis ma sili atu nai lo190ituaiga o ntm na iloa.
Lisi 1: Faʻamatalaga o 18 + 6 vailaʻau + 190 + NTM
Oloa lelei
Faʻatupuina le faʻamalosiʻau fetuunaiga: O faʻataʻitaʻiga a le sputm e mafai ona maua saʻo i le faʻatagaina o le tagata e aunoa ma le aganuu.
O le faʻataʻitaʻiga faʻataʻitaʻi e faigofie lava: o le taamilosaga muamua o le faʻatulagaina o faʻagasologa o le faigofie, ma o le fale faufalevai e maeʻa ile 3 itula, lea e faʻalelei atili ai le galuega faʻatino.
O le le mautonu ma le faasagatauina o vailaʻau: Faʻapipiʻi le taina o nofoaga o le MTB ma NTM, o le au tutoʻatasi o loʻo sailia ma fualaau lilo.
Tausaga: Oloa ogatasi, Fetuunai i Mainstam Ilm ma MGI / ITT Platforms.
Oloa faamatalaga
Oloa code | Igoa o oloa | Mauaina tulaga | faamatalaga fautuaina |
Hwts-ngs-t001 | Mycobacterailine typping ma fualaau faasaina o le resicticy disctication ki (tele le tele o le metotia) | Ont, ishumina, mgi, masima pro | 16 / 96rxn |
Taimi o le taimi: Ian-23-20244